Structure and Mechano-gating Mechanism of the Mechano-sensitive Mouse Piezo1 Channel with Small Molecule Agonist
نویسندگان
چکیده
منابع مشابه
Single molecule FRET reveals pore size and opening mechanism of a mechano-sensitive ion channel
The mechanosensitive channel of large conductance, which serves as a model system for mechanosensitive channels, has previously been crystallized in the closed form, but not in the open form. Ensemble measurements and electrophysiological sieving experiments show that the open-diameter of the channel pore is >25 Å, but the exact size and whether the conformational change follows a helix-tilt or...
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ژورنال
عنوان ژورنال: Journal of Cell Science & Therapy
سال: 2018
ISSN: 2157-7013
DOI: 10.4172/2157-7013.1000285